Abstract
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-gamma in mouse macrophages.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Interferon-gamma / pharmacology
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Macrophages / drug effects*
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Macrophages / metabolism
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Mice
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Saponins / chemistry*
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / pharmacology*
Substances
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Saponins
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Triterpenes
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Nitric Oxide
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Interferon-gamma