CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

M F Kuo; R M Wu; H S Wang; S M Lin

doi:10.1016/s0168-0102(99)00084-x

CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat

Neurosci Res. 1999 Dec 30;35(4):347-50. doi: 10.1016/s0168-0102(99)00084-x.

Authors

M F Kuo¹, R M Wu, H S Wang, S M Lin

Affiliation

¹ Department of Neurosurgery, National Taiwan University Hospital, Taipei.

PMID: 10617326
DOI: 10.1016/s0168-0102(99)00084-x

Abstract

Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Dopamine / metabolism*
Excitatory Amino Acid Antagonists / pharmacology
Hypoxia, Brain / drug therapy*
Hypoxia, Brain / physiopathology
Neostriatum / drug effects*
Neostriatum / physiopathology
Neuroprotective Agents / pharmacology
Piperazines / pharmacology*
Rats
Rats, Wistar

Substances

Excitatory Amino Acid Antagonists
Neuroprotective Agents
Piperazines
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
Dopamine