Abstract
We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Cell Line
-
Chromosome Mapping
-
Chromosomes, Human, Pair 2*
-
Cloning, Molecular
-
Conserved Sequence
-
Exons
-
Female
-
Genomic Library
-
Humans
-
Interleukin-1 / chemistry
-
Interleukin-1 / genetics*
-
Interleukin-1 / metabolism
-
Introns
-
Male
-
Mice
-
Models, Molecular
-
Molecular Sequence Data
-
Multigene Family*
-
Open Reading Frames
-
Protein Conformation
-
Protein Isoforms / chemistry
-
Protein Isoforms / genetics
-
Protein Isoforms / metabolism
-
Protein Structure, Secondary
-
Receptors, Interleukin-1 / metabolism
-
Recombinant Proteins / chemistry
-
Recombinant Proteins / metabolism
-
Sequence Alignment
-
Sequence Homology, Amino Acid
-
Tumor Cells, Cultured
Substances
-
Interleukin-1
-
Protein Isoforms
-
Receptors, Interleukin-1
-
Recombinant Proteins
Associated data
-
GENBANK/AF201830
-
GENBANK/AF201831
-
GENBANK/AF201832
-
GENBANK/AF201833