Abstract
Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1, 2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.
MeSH terms
-
Animals
-
Arachidonic Acid / metabolism
-
Candida albicans / physiology*
-
Cell Line
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects*
-
Macrophages / physiology
-
Mannosides / pharmacology*
-
Mice
-
Nitric Oxide / biosynthesis
-
Oligosaccharides / pharmacology*
-
Protein-Tyrosine Kinases / physiology
-
Tumor Necrosis Factor-alpha / biosynthesis
Substances
-
Lipopolysaccharides
-
Mannosides
-
Oligosaccharides
-
Tumor Necrosis Factor-alpha
-
Arachidonic Acid
-
Nitric Oxide
-
Protein-Tyrosine Kinases