Angioneurotic edema, though a fairly common medical condition, is rarely seen in dental practice. As laryngeal involvement can occur spontaneously and suddenly in the dental office or a similar complication can develop abruptly after administration of certain drugs used in dentistry, an understanding of this condition is definitely indicated. Moreover, as the hereditary form of this clinical entity can be precipitated by trauma, such as various dental and oral surgical procedures with a high incidence of laryngeal edema, an awareness of this phenomenon is an absolute necessity for sound medical and dental practice.