Abstract
While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, CD / analysis
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Bone Marrow Cells / pathology
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Female
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Histiocytosis, Non-Langerhans-Cell / complications*
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Histiocytosis, Non-Langerhans-Cell / pathology
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Humans
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Liver Neoplasms / complications*
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / pathology
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / diagnostic imaging
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Lymphoma, B-Cell / pathology
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Splenic Neoplasms / complications*
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Splenic Neoplasms / diagnostic imaging
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Splenic Neoplasms / pathology
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Splenomegaly / diagnostic imaging
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Tomography, X-Ray Computed
Substances
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Antigens, CD
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Biomarkers, Tumor