Fatal disseminated infection by Scedosporium prolificans during induction therapy for acute leukemia: a case report and literature review

Pathology. 1999 Nov;31(4):393-4. doi: 10.1080/003130299104783.

Abstract

We report a case of fatal disseminated fungal infection by Scedosporium prolificans which occurred in a patient with acute leukemia during induction chemotherapy. Rapid clinical deterioration despite high-dose empirical amphotericin B highlights both the pathogenicity of this fungus in immunocompromised hosts and its resistance to standard antifungal therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Amphotericin B / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cytarabine / therapeutic use
  • Daunorubicin / therapeutic use
  • Drug Resistance, Microbial
  • Fatal Outcome
  • Female
  • Fungemia / drug therapy
  • Fungemia / etiology*
  • Humans
  • Immunocompromised Host
  • Leukemia, Myeloid, Acute / drug therapy*
  • Mycetoma / drug therapy
  • Mycetoma / etiology*
  • Pseudallescheria / isolation & purification*
  • Pseudallescheria / pathogenicity

Substances

  • Cytarabine
  • Amphotericin B
  • Daunorubicin