Adolescents and young adults are at particular risk for hepatitis B infection. The Advisory Committee on Immunization Practices recommends vaccinating all children and adolescents. There are obstacles to vaccinating adolescents in clinical practice. School-based vaccination programs, either through school-based clinics or temporary vaccine clinics, can overcome these obstacles. To facilitate these programs, the Advisory Committee on Immunization Practices allows a 0, 2, 4 month vaccination schedule which has been shown to be similarly seroprotective as the standard 0, 1, 6 month schedule.