Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats

Pharm Res. 1999 Dec;16(12):1894-7. doi: 10.1023/a:1011967813140.
No abstract available

MeSH terms

  • Algorithms
  • Animals
  • Anti-Infective Agents / antagonists & inhibitors*
  • Anti-Infective Agents / toxicity*
  • Convulsants / toxicity*
  • Drug Interactions
  • Male
  • Models, Biological
  • Norfloxacin / antagonists & inhibitors*
  • Norfloxacin / pharmacokinetics
  • Norfloxacin / toxicity*
  • Pefloxacin / antagonists & inhibitors*
  • Pefloxacin / pharmacokinetics
  • Pefloxacin / toxicity*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Anti-Infective Agents
  • Convulsants
  • Pefloxacin
  • Norfloxacin