Myoglobinuria

Neurol Clin. 2000 Feb;18(1):215-43. doi: 10.1016/s0733-8619(05)70187-0.

Abstract

Myoglobinuria refers to an abnormal pathologic state in which an excessive amount of myoglobin is found in the urine, imparting a cola-like hue, usually in association with myonecrosis and a clinical picture of weakness, myalgias, and edema. Myoglobinuria is produced by multiple causes: any condition that accelerates the use or interferes with the availability of oxygen or energy substrates to muscle cells can result in myoglobinuria, as can events that produce direct muscle injury, either mechanical or chemical. Acute renal failure is the most serious complication, which can be prevented by prompt, aggressive treatment. In patients surviving acute attacks, recovery of muscle and renal function is usually complete.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Diagnosis, Differential
  • Energy Metabolism / physiology
  • Humans
  • Kidney Tubular Necrosis, Acute / diagnosis
  • Kidney Tubular Necrosis, Acute / etiology
  • Kidney Tubular Necrosis, Acute / pathology
  • Kidney Tubules / pathology
  • Muscle, Skeletal / pathology
  • Muscular Diseases / diagnosis
  • Muscular Diseases / etiology*
  • Muscular Diseases / pathology
  • Myoglobinuria / diagnosis
  • Myoglobinuria / etiology*
  • Myoglobinuria / pathology
  • Oxygen Consumption / physiology