A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970)

J Med Chem. 2000 Feb 10;43(3):342-5. doi: 10.1021/jm991151j.
No abstract available

MeSH terms

  • Cell Line
  • Humans
  • Models, Molecular
  • Phenols / chemical synthesis*
  • Phenols / chemistry
  • Phenols / metabolism
  • Radioligand Assay
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / metabolism
  • Serotonin Antagonists / chemical synthesis*
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / metabolism
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry
  • Sulfonamides / metabolism

Substances

  • Phenols
  • Receptors, Serotonin
  • Recombinant Proteins
  • SB 269970
  • Serotonin Antagonists
  • Sulfonamides
  • serotonin 7 receptor