Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity

Bioorg Med Chem Lett. 2000 Jan 17;10(2):119-21. doi: 10.1016/s0960-894x(99)00658-7.

Abstract

8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Amyloid beta-Peptides / pharmacology*
  • Cell Death / drug effects
  • Cell Line
  • Humans
  • Molecular Structure
  • Neuroprotective Agents / chemical synthesis
  • Neuroprotective Agents / pharmacology*
  • Pentacyclic Triterpenes
  • Peptide Fragments / antagonists & inhibitors
  • Peptide Fragments / pharmacology*
  • Plants, Medicinal / chemistry
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*

Substances

  • Amyloid beta-Peptides
  • Neuroprotective Agents
  • Pentacyclic Triterpenes
  • Peptide Fragments
  • Triterpenes
  • amyloid beta-protein (25-35)
  • asiatic acid