Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability

Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S95-S101. doi: 10.1164/ajrccm.161.supplement_1.ltta-19.

Authors

C N Serhan¹, T Takano, N Chiang, K Gronert, C B Clish

Affiliation

¹ Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 10673235
DOI: 10.1164/ajrccm.161.supplement_1.ltta-19

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Arachidonic Acids / blood*
Arachidonic Acids / pharmacology
Aspirin / pharmacology*
Biopsy, Needle
Capillary Permeability / drug effects*
Depression, Chemical
Disease Models, Animal
Ear Diseases / chemically induced
Ear Diseases / physiopathology
Ear, External / pathology
Eicosapentaenoic Acid / analogs & derivatives*
Eicosapentaenoic Acid / blood
Eicosapentaenoic Acid / pharmacology
Inflammation / chemically induced
Inflammation / physiopathology
Inflammation Mediators / metabolism*
Lipids / biosynthesis*
Mice
Mice, Inbred BALB C
Mice, Knockout
Neutrophil Infiltration / drug effects*
Peritonitis / chemically induced
Peritonitis / physiopathology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Arachidonic Acids
Inflammation Mediators
Lipids
Eicosapentaenoic Acid
Aspirin

Grants and funding