Abstract
Materno-fetal platelet allo-immunization causes fetal or neonatal thrombocytopenia and sometimes severe intracerebral bleeding. The HPA-1s antigen is most generally implicated. This accident can occur during the first pregnancy with a major risk of severe recurrence during the next pregnancy. These women require specific care in a specialized center although no consensus has been reached on management of second pregnancies. Proposed treatments include immunoglobulins and/or corticosteroids, fetal blood puncture and unique or iterative platelet transfusions.
MeSH terms
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Abortion, Therapeutic
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Antigens, Human Platelet / immunology*
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Blood Platelets / immunology*
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Cerebral Hemorrhage / diagnostic imaging
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Cerebral Hemorrhage / etiology*
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Cerebral Hemorrhage / therapy
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Female
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Fetal Diseases / immunology*
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Humans
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Immunoglobulin G / immunology*
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Infant, Newborn
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Integrin beta3
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Maternal-Fetal Exchange*
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Parity
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Pregnancy
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Pregnancy Trimester, Third
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Recurrence
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Risk Factors
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Thrombocytopenia / complications*
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Thrombocytopenia / immunology*
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Ultrasonography, Prenatal
Substances
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Antigens, Human Platelet
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ITGB3 protein, human
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Immunoglobulin G
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Integrin beta3