Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms

Curr Opin Neurol. 1999 Dec;12(6):739-43. doi: 10.1097/00019052-199912000-00014.

Abstract

Cholinergic hyperexcitation can be induced by both acute psychological stress and exposure to acetylcholinesterase inhibitors. Both factors are known risk factors for delayed neurodeterioration processes such as Alzheimer's disease and Parkinson's disease. Recent publications on the involvement of cholinergic pathways in these and other neurodeterioration syndromes are reviewed.

Publication types

  • Review

MeSH terms

  • Brain / drug effects
  • Brain / physiopathology
  • Cholinergic Fibers / drug effects*
  • Cholinergic Fibers / physiology
  • Humans
  • Neural Pathways / drug effects*
  • Neural Pathways / physiology
  • Neurodegenerative Diseases / chemically induced*
  • Neurodegenerative Diseases / physiopathology
  • Neurodegenerative Diseases / psychology*
  • Oxidative Stress / physiology*
  • Stress, Psychological / physiopathology*