Abstract
The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actin Depolymerizing Factors
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins / metabolism*
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Animals
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Contractile Proteins*
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Cytoskeletal Proteins*
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Dendrites / metabolism
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Destrin
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Humans
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Microfilament Proteins / metabolism
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Models, Biological
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Molecular Motor Proteins / metabolism
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Profilins
Substances
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ACTR2 protein, human
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ACTR3 protein, human
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Actin Depolymerizing Factors
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins
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Contractile Proteins
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Cytoskeletal Proteins
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Destrin
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Microfilament Proteins
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Molecular Motor Proteins
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PFN1 protein, human
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Profilins