Influence of the HDL receptor SR-BI on atherosclerosis

Curr Opin Lipidol. 1999 Dec;10(6):491-7. doi: 10.1097/00041433-199912000-00003.

Abstract

The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration. SR-BI can also serve as a receptor for non-HDL lipoproteins and appears to play an important role in reverse cholesterol transport. Recent studies involving the manipulation of SR-BI expression in mice, either using adenovirus-mediated or transgenic hepatic overexpression or using homologous recombination for complete functional ablation, indicate that the expression of SR-BI protects against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / physiopathology*
  • CD36 Antigens / physiology*
  • Carrier Proteins*
  • Female
  • Fertility
  • Humans
  • Lipoproteins, HDL*
  • Membrane Proteins*
  • Mice
  • Mice, Transgenic
  • RNA-Binding Proteins*
  • Receptors, Immunologic*
  • Receptors, Lipoprotein / physiology*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B

Substances

  • CD36 Antigens
  • Carrier Proteins
  • Lipoproteins, HDL
  • Membrane Proteins
  • RNA-Binding Proteins
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • SCARB1 protein, human
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • high density lipoprotein receptors
  • high density lipoprotein binding protein