Acute heart transplant rejection due to Saint John's wort

Lancet. 2000 Feb 12;355(9203):548-9. doi: 10.1016/S0140-6736(99)05467-7.

Abstract

We report here acute rejection in two transplant patients due to a metabolic interaction of St John's wort and cyclosporin.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Azathioprine / blood
  • Cyclosporine / blood*
  • Drug Interactions
  • Graft Rejection / chemically induced*
  • Heart Transplantation*
  • Humans
  • Hypericum / adverse effects*
  • Immunosuppressive Agents / blood*
  • Male
  • Middle Aged
  • Plants, Medicinal*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Azathioprine