Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome

J Pediatr Endocrinol Metab. 2000 Jan;13(1):101-3. doi: 10.1515/jpem.2000.13.1.101.

Abstract

Gynecomastia in boys with Peutz-Jeghers syndrome and Sertoli cell tumors of gonadal origin results from increased estrogen production due to increased aromatase activity within the testicular tumor. We present a prepubertal boy with Peutz-Jeghers syndrome, gynecomastia and bilateral neoplastic Sertoli cell proliferation in whom the only abnormal hormonal profile was increased concentration of inhibin B and Pro-alpha C in serum.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Cell Division
  • Child
  • Estradiol / blood
  • Estrone / analogs & derivatives
  • Estrone / blood
  • Follicle Stimulating Hormone / blood
  • Gynecomastia / blood*
  • Gynecomastia / surgery
  • Humans
  • Inhibins / blood*
  • Luteinizing Hormone / blood
  • Male
  • Peutz-Jeghers Syndrome / blood*
  • Sertoli Cell Tumor / pathology
  • Testicular Neoplasms / pathology

Substances

  • estrone-3-glucuronide
  • Estrone
  • Estradiol
  • Inhibins
  • Luteinizing Hormone
  • Follicle Stimulating Hormone