No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study

H Goodwin; N Curran; B Chioza; J Blower; L Nashef; P Asherson; A J Makoff

doi:10.1016/s0920-1211(99)00096-0

No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study

Epilepsy Res. 2000 Mar;39(1):27-31. doi: 10.1016/s0920-1211(99)00096-0.

Authors

H Goodwin¹, N Curran, B Chioza, J Blower, L Nashef, P Asherson, A J Makoff

Affiliation

¹ Department of Psychological Medicine, Institute of Psychiatry, London, UK.

PMID: 10690750
DOI: 10.1016/s0920-1211(99)00096-0

Abstract

The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performed on DNA from more than 100 patients with idiopathic generalised epilepsy (IGE). No significant association was found with IGE for either polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
Epilepsy, Generalized / genetics*
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Polymorphism, Genetic / genetics*
Receptors, Metabotropic Glutamate / genetics*

Substances

Receptors, Metabotropic Glutamate
metabotropic glutamate receptor 7
metabotropic glutamate receptor 8