Walking with labor epidural analgesia: the impact of bupivacaine concentration and a lidocaine-epinephrine test dose

Anesthesiology. 2000 Feb;92(2):387-92. doi: 10.1097/00000542-200002000-00019.

Abstract

Background: Regional analgesia techniques for labor that permit ambulation are popular among parturients. This study evaluated the influence of bupivacaine bolus concentration and a 3-ml 1.5% lidocaine-epinephrine test dose, on analgesic effectiveness and the ability to walk after block placement.

Methods: Using a randomized double-blind study design, epidural analgesia was initiated in 60 parturients undergoing labor as follows: Group TD/B.0625 received a 3-ml lidocaine-epinephrine test dose + 12 ml bupivacaine, 0.0625%; group TD/B.125 received a 3-ml test dose + 12 ml bupivacaine, 0.125%; group B.0625 received 15 ml bupivacaine, 0.0625% (no test dose); and group B.125 received 15 ml bupivacaine, 0.125% (no test dose). Initial boluses in all groups contained 10 microg sufentanil. Bupivacaine, 0.0625%, with 0.33 microg/ml sufentanil was infused throughout labor at 13.5-15 ml/h. Analgesia balance, proprioception, motor block, and patient ability to stand and walk were evaluated at various intervals.

Results: A bolus of 0.125% bupivacaine containing sufentanil, without a previous test dose, proved to be optimal with respect to analgesia and early ambulation. When a test dose was given before bupivacaine, 0.125%, fewer women walked within 1 h of block placement. Bupivacaine, 0.0625%, with sufentanil, with or without a test dose, provided inadequate analgesia, necessitating additional bupivacaine, which impaired the ability to walk. A high percentage of women in all groups (73-93%) walked at some stage during labor.

Conclusions: Omitting a lidocaine-epinephrine test dose and using 0.125% bupivacaine for the initial bolus should permit ambulation in the early postblock period for most parturients who elect this option.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesia, Epidural*
  • Analgesia, Obstetrical*
  • Anesthetics, Local* / administration & dosage
  • Bupivacaine* / administration & dosage
  • Double-Blind Method
  • Epinephrine* / administration & dosage
  • Female
  • Humans
  • Lidocaine* / administration & dosage
  • Pain Measurement
  • Pregnancy
  • Urination
  • Vasoconstrictor Agents* / administration & dosage
  • Walking*

Substances

  • Anesthetics, Local
  • Vasoconstrictor Agents
  • Lidocaine
  • Bupivacaine
  • Epinephrine