Synthetic analogues of netropsin and distamycin. V. Synthesis of a carbocyclic bis-lexitropsin as potential DNA cleaving agent

Rocz Akad Med Bialymst. 1999:44:200-15.

Abstract

A carbocyclic analogue of bis-distamycin, in which N-methylpyrroles were replaced by two trisubstituted benzene moieties joined by tetramethylenedioxy linkage, has been prepared. This compound bearing photosensitive benzotriazole moieties at the N-terminal residues. The synthetic method for the preparation of the bis-benzotriazolyllexitropsin was accomplished in twelve steps starting from 2-hydroxy-5-phenylazobenzoic acid.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antiviral Agents / chemistry*
  • Cell Division
  • Distamycins / chemistry*
  • Humans
  • Netropsin / analogs & derivatives*
  • Netropsin / chemical synthesis

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Distamycins
  • lexitropsin
  • Netropsin
  • stallimycin