Abstract
Several studies have now been published on the effect of one or several years of growth hormone treatment on growth and body composition of children with Prader-Willi syndrome. The majority of the patients have responded with greatly increased growth rate, decreased body fat and increased muscle volume. Many of these children seem to have a functional growth hormone deficiency, probably secondary to their hypothalamic dysfunction. Further studies are needed to establish the long-term effect of this treatment on somatic and psychological well-being.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Body Composition / drug effects
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Body Height / drug effects
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Body Weight / drug effects
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Child
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Hormone Replacement Therapy / adverse effects
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Hormone Replacement Therapy / psychology
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Human Growth Hormone / adverse effects
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Human Growth Hormone / deficiency
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Human Growth Hormone / pharmacology
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Human Growth Hormone / therapeutic use*
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Humans
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Hypercapnia / complications
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Hypercapnia / drug therapy
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Hypoventilation / complications
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Hypoventilation / drug therapy
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Prader-Willi Syndrome / complications
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Prader-Willi Syndrome / drug therapy*
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Prader-Willi Syndrome / physiopathology
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Prader-Willi Syndrome / psychology