The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization

Cytogenet Cell Genet. 1999;87(3-4):238-44. doi: 10.1159/000015434.

Abstract

Herein we report the cloning of cDNAs and incompletely processed hnRNAs from endothelia and heart that encode the alpha10 subunit forming part of the novel collagen type II-binding integrin alpha10beta1 of chondrocytes. Analysis of hnRNA clones and reported expressed sequence tags revealed the positions of 17 putative intron-exon splice junctions shared with those of the p150,95 (ITGAX) gene. Human alpha10 transcripts of 5.4 and 1.8 kb were not restricted to chondrocytes but, instead, were widely expressed in a panel of 24 tissue types, where the highest expression was found in muscle and heart. The human alpha10 subunit gene (ITGA10) was localized to band q21 of chromosome 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chromosomes, Human, Pair 1 / genetics
  • Cloning, Molecular
  • Conserved Sequence / genetics
  • DNA, Complementary / genetics
  • Endothelium, Vascular / metabolism
  • Exons / genetics*
  • Expressed Sequence Tags
  • Gene Expression Profiling*
  • Gene Library
  • Humans
  • In Situ Hybridization, Fluorescence
  • Integrin alpha Chains*
  • Integrins / chemistry
  • Integrins / genetics*
  • Introns / genetics*
  • Molecular Sequence Data
  • Myocardium / metabolism
  • Physical Chromosome Mapping*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Sequence Alignment

Substances

  • DNA, Complementary
  • Integrin alpha Chains
  • Integrins
  • RNA, Messenger
  • integrin alpha 10

Associated data

  • GENBANK/AF112345
  • GENBANK/AF172723