Regardless of the etiology of an enteric disease in nursery age to finisher swine, making a prompt and accurate diagnosis is crucial. Eliciting a complete history, assessing clinical signs and pathology, and selecting and interpreting laboratory tests are essential components in achieving this. Early detection and diagnosis of enteric disease is particularly critical in the nursery through finisher phase because of economic impacts. Recurrent topics when discussing control and prevention of enteric diseases are reducing stress and improving pig comfort and reducing or eliminating exposure through sanitation and biosecurity. These are not new concepts; in fact, prior to the advent of antimicrobials, they were the mainstay of treatment of enteric diseases. With concern over the use of antimicrobials in food animal production increasing, exploiting disease ecology to control enteric diseases is increasing in importance. New vaccines and bacterins for postweaning swine enteric diseases are needed tools to exploit the pig's immune system. Recent advances in diagnostic capabilities allow an increase in understanding and exploitation of disease ecology.