Abstract
Antipsychotic efficacy and side effects of the selective sigma ligand EMD 57445 (panamesine) were investigated in 12 patients (6 males, 6 females) who met DSM-III-R criteria for schizophrenia. A 4-week open clinical study revealed only modest effects of EMD 57445 and its metabolites on positive and negative symptoms of schizophrenia. Extrapyramidal and other side effects were moderate, although a significant increase in mild dyskinetic movements was found. Five patients, four of whom were females, completed the trial. Dropouts were mainly due to treatment failure. Antipsychotic effects were significantly greater in female than male patients.
MeSH terms
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Acute Disease
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Adult
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Aged
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Antipsychotic Agents / adverse effects
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Antipsychotic Agents / pharmacokinetics
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Antipsychotic Agents / therapeutic use*
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Basal Ganglia Diseases / blood
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Basal Ganglia Diseases / chemically induced
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Biotransformation
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Humans
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Male
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Middle Aged
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Oxazoles / adverse effects
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Oxazoles / pharmacokinetics
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Oxazoles / therapeutic use*
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Piperidines / adverse effects
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Piperidines / pharmacokinetics
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Piperidines / therapeutic use*
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Psychiatric Status Rating Scales
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Receptors, sigma / drug effects
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Schizophrenia / blood
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy*
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Schizophrenic Psychology
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Treatment Outcome
Substances
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Antipsychotic Agents
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Oxazoles
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Piperidines
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Receptors, sigma
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panamesine