Abstract
A significant level of genetic variation among HIV-1 and HIV-2 has been described. The interaction of specific HIV-2 subtypes with HIV-1 may serve to identify potential biological properties associated with dual infection. To genetically characterize the HIV-2 strains circulating in Senegal and their relationship to coinfection with HIV-1, we sequenced the HIV-2 envelope C2-C3 region of 12 subjects coinfected with HIV-1 and HIV-2 and 9 subjects singly infected with HIV-2. The phylogenetic analysis showed that all subjects were infected with HIV-2 subtype A, confirming its predominance in West Africa. We did not observe specific sequences or genetic clustering based on coinfection status.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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DNA, Viral
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Female
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Gene Products, env / genetics*
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HIV Envelope Protein gp120 / genetics
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HIV Infections / complications
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HIV Infections / virology*
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HIV-2 / classification
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HIV-2 / genetics*
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Humans
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Molecular Sequence Data
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Peptide Fragments / genetics
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Phylogeny
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Prospective Studies
Substances
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DNA, Viral
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Gene Products, env
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
Associated data
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GENBANK/AF185801
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GENBANK/AF185802
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GENBANK/AF185803
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GENBANK/AF185804
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GENBANK/AF185805
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GENBANK/AF185806
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GENBANK/AF185807
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GENBANK/AF185808
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GENBANK/AF185809
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GENBANK/AF185810
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GENBANK/AF185811
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GENBANK/AF185812
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GENBANK/AF185813
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GENBANK/AF185814
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GENBANK/AF185815
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GENBANK/AF185816
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GENBANK/AF185817
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GENBANK/AF185818
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GENBANK/AF185819
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GENBANK/AF185820
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GENBANK/AF185821