Objective: To observe the effects of sandostatin on gastric mucosal blood flow (GMBF) in rats with (portal hypertensive gastropathy, PHG) and its mechanisms.
Methods: Two weeks after portal vein ligation, the changes of systemic hemodynamics, GMBF, (portal vein pressure, PVP) were observed and plasma glucagon, plasma and gastric mucosal NO2-/NO3-, 6-Keto-PGF(1alpha) were measured after intravenous sandostatin, propranolol and normal saline.
Results: GMBF and PVP were reduced after intravenous sandostatin or propranolol. Sandostatin decreased plasma glucagon, plasma and gastric mucosal NO2-/NO3-, and had no effect on MAP and heart rate of PHG rats as compared with control group of PHG. Propranolol had not these effects, but it might decrease MAP and heart rate. There were no differences of plasma and gastric mucosal 6-Keto-PGF(1alpha) between all PHG groups.
Conclusion: Sandostatin reduced GMBF of rats with PHG by hindering glucagon, NO, and had no effect on systemic hemodynamics.