Abstract
The synthesis and antihypertensive activity of racemates and enantiomers of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylates have been reported.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antihypertensive Agents / chemistry*
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Antihypertensive Agents / pharmacokinetics
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Antihypertensive Agents / therapeutic use*
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Blood Pressure / drug effects
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Drug Evaluation
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Heart Rate / drug effects
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Male
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Nifedipine / pharmacokinetics
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Nifedipine / therapeutic use
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Oxazoles / chemistry*
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Oxazoles / pharmacokinetics
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Oxazoles / therapeutic use*
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Pyridines / chemistry*
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Pyridines / pharmacokinetics
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Pyridines / therapeutic use*
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Rats
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Rats, Inbred SHR
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Stereoisomerism
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Structure-Activity Relationship
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Time Factors
Substances
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Antihypertensive Agents
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Oxazoles
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Pyridines
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Nifedipine