Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship

Bioorg Med Chem Lett. 2000 Feb 21;10(4):373-5. doi: 10.1016/s0960-894x(00)00003-2.

Abstract

Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated. Biaromatic and methyl groups, attached to the oxime moiety, and the ethylene bridge between oxime and phenoxy groups are favorable to biological activities.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Drug Evaluation
  • Hyperglycemia / blood
  • Hyperglycemia / drug therapy
  • Hypoglycemic Agents / chemical synthesis
  • Hypoglycemic Agents / chemistry*
  • Hypoglycemic Agents / pharmacology*
  • Insulin Resistance / physiology
  • Isomerism
  • Mice
  • Mice, Inbred Strains
  • Oximes / chemical synthesis
  • Oximes / chemistry*
  • Oximes / pharmacology*
  • Receptors, Cytoplasmic and Nuclear / agonists
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Structure-Activity Relationship
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology*
  • Transcription Factors / agonists
  • Transcription Factors / metabolism

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Oximes
  • Receptors, Cytoplasmic and Nuclear
  • Thiazoles
  • Transcription Factors