Sudden infant death syndrome: can gastroesophageal reflux cause sudden infant death?

Am J Med. 2000 Mar 6:108 Suppl 4a:144S-148S. doi: 10.1016/s0002-9343(99)00354-x.

Abstract

Although gastric contents in the airways and lungs of sudden infant death syndrome (SIDS) victims is commonly found during postmortem examination, its significance as a sole or contributory cause of death has long been controversial. Currently, most authorities view such aspiration as resulting from "agonal" processes and, therefore, irrelevant to cause of death. Recent clinical and experimental evidence indicates that infants who are near death because of a variety of conditions, frequently "autoresuscitate," which produces rapid and complete recovery. In animal models, aspiration of water or saline into the airways has been shown to prevent autoresuscitation. In light of these findings, aspiration of gastric contents should be reconsidered as a contributory cause of many SIDS deaths.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Forensic Medicine
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / physiopathology
  • Humans
  • Infant
  • Infant, Newborn
  • Inhalation
  • Sudden Infant Death / etiology*