Abstract
The role of IFN-gamma in the expression of indoleamine 2,3-dioxygenase (IDO), a tryptophan oxidizing enzyme, in mouse tissues under physiological and pathological conditions was investigated using IFN-gamma-knockout mice. The results revealed that i) the expression of IDO in the large intestine or in the cecum is mediated by IFN-gamma, ii) for the systemic IDO induction under endotoxin shock, IFN-gamma is a dominant inducer but not essential, and an IFN-gamma-independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 or Pokeweed mitogen is mediated by IFN-gamma, and iv) the constitutive IDO expression in the epididymis is IFN-gamma-independent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Enzyme Induction / drug effects
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Enzyme Induction / immunology
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Epididymis / enzymology
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Gene Expression Regulation, Enzymologic / immunology*
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interferon-gamma / deficiency
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Interferon-gamma / genetics
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Interferon-gamma / physiology*
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Interleukin-12 / pharmacology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C3H
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Mice, Inbred C57BL
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Mice, Knockout
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Poly I-C / pharmacology
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Shock, Septic / enzymology
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Tryptophan Oxygenase / biosynthesis
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Tryptophan Oxygenase / genetics*
Substances
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interleukin-12
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Interferon-gamma
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Tryptophan Oxygenase
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Poly I-C