Abstract
A pregnant mare showing pyrexia, reduced appetite, ataxia and paresis was euthanized and examined for the presence of Borna disease virus (BDV). Her brain, showing multiple neuronal degeneration and necrosis with hemorrhage, and the histologically normal brain of the fetus were both positive for BDV RNA. The BDV nucleotide sequences were identical in the mare and fetus in the second open reading frame (ORF). This is the first report of the possible vertical transmission of BDV in a horse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / blood
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Antibodies, Viral / cerebrospinal fluid
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Base Sequence
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Borna Disease / transmission*
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Borna disease virus / isolation & purification*
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Brain / pathology
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Brain / virology
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DNA Primers / chemistry
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DNA, Viral / chemistry
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Female
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Fetal Diseases / virology*
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Horse Diseases / transmission*
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Horse Diseases / virology
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Horses
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Immunoblotting / veterinary
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Immunohistochemistry
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In Situ Hybridization / veterinary
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Infectious Disease Transmission, Vertical / veterinary*
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Molecular Sequence Data
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Pregnancy
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Pregnancy Complications, Infectious / virology*
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RNA, Viral / chemistry
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RNA, Viral / isolation & purification
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Reverse Transcriptase Polymerase Chain Reaction / veterinary
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Nucleic Acid
Substances
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Antibodies, Viral
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DNA Primers
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DNA, Viral
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RNA, Viral