Abstract
A recombinant (r-) Salmonella typhimurium aroA vaccine that secretes the naturally secreted protein of Mycobacterium bovis strain BCG, Ag85B, by means of the HlyB/HlyD/TolC export machinery (termed p30 in the following) was constructed. In contrast to r-S. typhimurium control, oral vaccination of mice with the r-S. typhimurium p30 construct induced partial protection against an intravenous challenge with the intracellular pathogen Mycobacterium tuberculosis, resulting in similar vaccine efficacy comparable to that of the systemically administered attenuated M. bovis BCG strain. The immune response induced by r-S. typhimurium p30 was accompanied by augmented interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels produced by restimulated splenocytes. These data suggest that the HlyB/HlyD/TolC-based antigen delivery system with attenuated r-S. typhimurium as carrier is capable of inducing an immune response against mycobacterial antigens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyltransferases*
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Animals
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Antigens, Bacterial*
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology*
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Bacterial Proteins / metabolism
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / genetics
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Bacterial Vaccines / immunology*
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Interferon-gamma / biosynthesis
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Mice
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Mice, Inbred C57BL
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Mycobacterium bovis / genetics
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Mycobacterium bovis / immunology
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Mycobacterium bovis / metabolism
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Plasmids
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Salmonella typhimurium / genetics*
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Salmonella typhimurium / immunology
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Tuberculosis / prevention & control*
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Tumor Necrosis Factor-alpha / biosynthesis
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Vaccination
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / immunology
Substances
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Antigens, Bacterial
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Bacterial Proteins
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Bacterial Vaccines
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Tumor Necrosis Factor-alpha
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Vaccines, Attenuated
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Vaccines, Synthetic
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Interferon-gamma
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Acyltransferases
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antigen 85B, Mycobacterium tuberculosis