Beta-blocker titration failure is independent of severity of heart failure

Am J Cardiol. 2000 Feb 15;85(4):509-12, A11. doi: 10.1016/s0002-9149(99)00784-5.

Abstract

In the present study, predictors of complicated initiation of beta blockade in patients with idiopathic dilated cardiomyopathy was studied. We found that generally accepted measures of severity of heart failure are not predictable, whereas low systolic blood pressure (< or =120 mm Hg) was the strongest predictor for problematic (up)titration.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adrenergic beta-Antagonists / administration & dosage*
  • Adult
  • Aged
  • Bisoprolol / administration & dosage*
  • Blood Pressure / drug effects
  • Cardiac Catheterization
  • Cardiac Output / drug effects
  • Cardiomyopathy, Dilated / diagnosis
  • Cardiomyopathy, Dilated / drug therapy*
  • Cardiomyopathy, Dilated / physiopathology
  • Dose-Response Relationship, Drug
  • Electrocardiography, Ambulatory
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Severity of Illness Index
  • Treatment Failure

Substances

  • Adrenergic beta-Antagonists
  • Bisoprolol