Abstract
We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyper-intense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.
MeSH terms
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Adolescent
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Adult
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Antineoplastic Agents / adverse effects*
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Brain Diseases / chemically induced
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Brain Diseases / diagnosis
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Brain Diseases / pathology
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Cerebral Cortex / diagnostic imaging
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Cerebral Cortex / drug effects
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Cerebral Cortex / pathology*
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Cyclosporine / adverse effects
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Female
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Humans
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Immunosuppressive Agents / adverse effects*
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Magnetic Resonance Imaging
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Male
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Methotrexate / adverse effects
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Middle Aged
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Necrosis
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Tacrolimus / adverse effects
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Tomography, X-Ray Computed
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Vincristine / adverse effects
Substances
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Antineoplastic Agents
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Immunosuppressive Agents
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Vincristine
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Cyclosporine
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Tacrolimus
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Methotrexate