Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

L Zhi; C M Tegley; B Pio; S J West; K B Marschke; D E Mais; T K Jones

doi:10.1016/s0960-894x(00)00011-1

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

Bioorg Med Chem Lett. 2000 Mar 6;10(5):415-8. doi: 10.1016/s0960-894x(00)00011-1.

Authors

L Zhi¹, C M Tegley, B Pio, S J West, K B Marschke, D E Mais, T K Jones

Affiliation

¹ Ligand Pharmaceuticals, San Diego, CA 92121, USA. [email protected]

PMID: 10743938
DOI: 10.1016/s0960-894x(00)00011-1

Abstract

Synthesis and biological evaluation of 6-thiophene 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives resulted in a number of potent nonsteroidal antiprogestins.

MeSH terms

Animals
Breast Neoplasms / metabolism
Cell Line
Cross Reactions
Fibroblasts
Haplorhini
Humans
Mice
Quinolines / chemical synthesis*
Quinolines / pharmacology
Receptors, Progesterone / antagonists & inhibitors*
Receptors, Progesterone / genetics
Structure-Activity Relationship
Thiophenes / chemical synthesis*
Thiophenes / pharmacology
Transfection
Tumor Cells, Cultured

Substances

Quinolines
Receptors, Progesterone
Thiophenes