Abstract
A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Glucose / chemistry
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Glucosides / chemical synthesis*
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Glucosides / pharmacology*
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Humans
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Indoles*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Stereoisomerism
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Topoisomerase I Inhibitors*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Carbazoles
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Enzyme Inhibitors
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Glucosides
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Indoles
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NB 506
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Topoisomerase I Inhibitors
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edotecarin
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Glucose