Treatment of acute disseminated encephalomyelitis with intravenous immunoglobulin

Neurology. 2000 Mar 28;54(6):1370-2. doi: 10.1212/wnl.54.6.1370.

Abstract

Acute disseminated encephalomyelitis (ADEM) is a presumed immune-mediated, demyelinating disease of the CNS for which the standard treatment is high-dose steroids. We describe two patients with ADEM in whom treatment with IV methylprednisolone coincided with deterioration in their clinical status. They were subsequently treated with IV immunoglobulin and exhibited dramatic clinical improvement, with return to their previous level of functioning.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Encephalomyelitis, Acute Disseminated / drug therapy*
  • Encephalomyelitis, Acute Disseminated / pathology
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Magnetic Resonance Imaging

Substances

  • Immunoglobulins, Intravenous