Abstract
The presence of cytotoxic necrotizing factor 1 (CNF1), together with various associated virulence factors (alpha-haemolysin, P-, S- and A-fimbriae), was screened in 175 uropathogenic Escherichia coli strains isolated from hospitalized adult patients. The cnf1 gene was detected in 30% of the selected strains independently of the severity of the clinical urinary infection. A significant association between CNF1, haemolytic activity and the products of the pap/sfa genes was found. However, CNF1 appeared not to play a major role in nosocomial E. coli urinary tract infections.
MeSH terms
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Adhesins, Bacterial / genetics
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Adhesins, Bacterial / metabolism
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Bacterial Toxins / genetics
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Bacterial Toxins / metabolism*
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Cross Infection / microbiology*
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Cross Infection / urine
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Cytotoxins / genetics
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Cytotoxins / metabolism*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification*
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Escherichia coli / metabolism
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Escherichia coli Infections / microbiology*
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Escherichia coli Infections / urine
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Escherichia coli Proteins*
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Female
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Genes, Bacterial
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Hemolysin Proteins / genetics
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Hemolysin Proteins / metabolism
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Humans
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Male
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Middle Aged
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Mutation
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Polymerase Chain Reaction
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Repressor Proteins*
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Transcription Factors*
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Urinary Tract Infections / microbiology*
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Virulence
Substances
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Adhesins, Bacterial
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Bacterial Proteins
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Bacterial Toxins
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Cytotoxins
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Escherichia coli Proteins
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Hemolysin Proteins
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PapI protein, E coli
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Repressor Proteins
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Transcription Factors
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ymcE protein, E coli
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cytotoxic necrotizing factor type 1