Gamma(delta) T cells: non-classical ligands for non-classical cells

Curr Biol. 2000 Apr 6;10(7):R282-5. doi: 10.1016/s0960-9822(00)00408-5.

Abstract

A recent study describes direct binding between a gammadelta T-cell receptor and its ligand, T22, a non-classical class I major histocompatibility complex (MHC) molecule. A companion study, solving the crystal structure of T22, highlights the differences between this interaction and those of classical MHC molecules and alphabeta T cells.

Publication types

  • Review

MeSH terms

  • Crystallography
  • Histocompatibility Antigens Class I / chemistry
  • Histocompatibility Antigens Class I / metabolism*
  • Models, Immunological*
  • Models, Molecular
  • Proteins / chemistry
  • Proteins / metabolism*
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Histocompatibility Antigens Class I
  • Proteins
  • Receptors, Antigen, T-Cell, gamma-delta
  • T22 antigen