Silencing of the Y-chromosomal gene tspy during murine evolution

S Schubert; F Dechend; B Skawran; B Kunze; H Winking; C Weile; I Römer; M Hemberger; R Fundele; T Sharma; J Schmidtke

doi:10.1007/s003350010054

Silencing of the Y-chromosomal gene tspy during murine evolution

Mamm Genome. 2000 Apr;11(4):288-91. doi: 10.1007/s003350010054.

Authors

S Schubert¹, F Dechend, B Skawran, B Kunze, H Winking, C Weile, I Römer, M Hemberger, R Fundele, T Sharma, J Schmidtke

Affiliation

¹ Institut für Humangenetik, Medizinische Hochschule, Hannover, Germany.

PMID: 10754104
DOI: 10.1007/s003350010054

Abstract

We have studied the process of tspy gene silencing in murine evolution. We have isolated functional tspy sequences from Apodemus agrarius, A. sylvaticus, A. flavicollis, and Mus platythrix (subgenus Pyromys) and nonfunctional tspy sequences from species of the subgenus Mus. We present two alternative models as to how tspy may have lost its function in the murine lineage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Biological Evolution*
DNA Primers
DNA-Binding Proteins / genetics*
Gene Silencing*
Mice
Molecular Sequence Data
Nuclear Proteins*
Polymerase Chain Reaction
Sex-Determining Region Y Protein
Transcription Factors*
Y Chromosome*

Substances

DNA Primers
DNA-Binding Proteins
Nuclear Proteins
Sex-Determining Region Y Protein
Transcription Factors

Associated data

GENBANK/AF152846
GENBANK/AF152847
GENBANK/AF205111
GENBANK/AF205112
GENBANK/AF205113
GENBANK/AF205114