Sin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome

P Bostik; J Winter; T G Ksiazek; P E Rollin; F Villinger; S R Zaki; C J Peters; A A Ansari

doi:10.3201/eid0602.000213

Sin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome

Emerg Infect Dis. 2000 Mar-Apr;6(2):184-7. doi: 10.3201/eid0602.000213.

Authors

P Bostik¹, J Winter, T G Ksiazek, P E Rollin, F Villinger, S R Zaki, C J Peters, A A Ansari

Affiliation

¹ Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

Serum samples from 22 hantavirus pulmonary syndrome (HPS) patients were tested for Sin Nombre virus (SNV)-reactive antibodies. In the acute phase of HPS, 100% and 67% of the samples tested positive for SNV-specific immunoglobulin (Ig) M and IgA, respectively. Among the virus-specific IgG antibodies, the most prevalent were IgG3 (in 97% of samples), followed by IgG1 (70%), IgG2 (30%), and IgG4 (3%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Antibodies, Viral / blood*
Antigens, Viral
Chronic Disease
Hantavirus Pulmonary Syndrome / immunology*
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin G / classification
Immunoglobulin Isotypes / blood*
Immunoglobulin M / blood
Orthohantavirus / immunology*
Prognosis

Substances

Antibodies, Viral
Antigens, Viral
Immunoglobulin A
Immunoglobulin G
Immunoglobulin Isotypes
Immunoglobulin M