Abstract
We compared in vitro sensitivities to Coxiella burnetii of alveolar macrophages, derived from mice sensitive and resistant to C. burnetii, respectively, and examined the role of nitric oxide (NO) in the C. burnetii infection. Alveolar macrophages of sensitive A/J mice showed a larger population of C. burnetii antigen-positive cells than those of resistant C57BL/6 mice. C. burnetii induced NO production in alveolar macrophages, but N-methyl-L-arginine and sodium nitroprusside (SNP), NO inhibitor and donor, respectively, did not inhibit the infection. Thus the NO induction seems to be independent of the cell defense mechanism against the C. burnetii infection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Cells, Cultured
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Chick Embryo
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Coxiella burnetii / metabolism
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Coxiella burnetii / physiology*
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Disease Susceptibility
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Enzyme Inhibitors / pharmacology
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Immunity, Innate
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Macrophages, Alveolar / metabolism*
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Macrophages, Alveolar / microbiology*
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Mice
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Mice, Inbred A
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide / biosynthesis*
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitroprusside / pharmacology
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Q Fever / immunology*
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Q Fever / microbiology
Substances
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Enzyme Inhibitors
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Nitroprusside
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Nitric Oxide
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Nitric Oxide Synthase
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NG-Nitroarginine Methyl Ester