This article is composed of a review of how the increasing numbers of people working abnormal hours (referred to as "shift workers") can best be helped by the science of chronobiology. While recognizing that chronobiologists can give much general advice regarding such things as diet, sleep hygiene, cardiovascular health, and the need to address social and domestic tensions, this article will focus specifically on the advice that can be given to employers and employees, which is directly rooted in our knowledge of chronobiology.