Abstract
Isonicotinoylhydrazones 1, obtained by the primary antituberculous agent Isoniazid, have been used as monoanionic ligands (L) to prepare copper(II) 2 and nickel(II) 3 octahedral complexes of stoichiometry [MeL2(H2O)2]. Their antimycobacterial in vitro activity was evaluated against Mycobacterium tuberculosis H37Rv in comparison with the ligands. Complexes 2a, 2b, 2f, 3b, 3d and 3g displayed MIC values < or = 0.2 microg/mL.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antitubercular Agents / chemical synthesis
-
Antitubercular Agents / chemistry
-
Antitubercular Agents / pharmacology*
-
Isoniazid / analogs & derivatives*
-
Isoniazid / chemistry
-
Isoniazid / pharmacology
-
Microbial Sensitivity Tests
-
Mycobacterium tuberculosis / drug effects*
-
Organometallic Compounds / chemistry
-
Organometallic Compounds / pharmacology*
-
Structure-Activity Relationship
Substances
-
Antitubercular Agents
-
Organometallic Compounds
-
Isoniazid