Abstract
The FemAB-like factors Lif and Epr confer resistance to glycylglycine endopeptidases lysostaphin and Ale-1, respectively, by incorporating serine residues into the staphylococcal peptidoglycan interpeptide bridges specifically at positions 3 and 5. This required the presence of FemA and/or FemB, in contrast to earlier postulations.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Drug Resistance, Microbial*
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Mutagenesis, Site-Directed
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Peptides / metabolism
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Peptidoglycan / metabolism*
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Serine / genetics
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Serine / metabolism*
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Staphylococcus / genetics
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Staphylococcus / metabolism
Substances
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Bacterial Proteins
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Epr protein, Staphylococcus capitis
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FemA protein, Bacteria
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FemB protein, Staphylococcus epidermidis
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Peptides
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Peptidoglycan
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Serine