Abstract
The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha 1 reduced them, whereas deletion of TRbeta actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.
MeSH terms
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Animals
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Body Weight / drug effects
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Estradiol / analogs & derivatives
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Estradiol / blood
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Estradiol / pharmacology
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Estrogens / blood
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Estrogens / pharmacology*
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Female
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Gene Deletion*
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Male
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Mice
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Mice, Inbred Strains
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Mice, Knockout
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Organ Size / drug effects
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Oxytocin / analysis
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Paraventricular Hypothalamic Nucleus / chemistry
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Paraventricular Hypothalamic Nucleus / cytology
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Posture
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Preoptic Area / chemistry
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Preoptic Area / cytology
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Progesterone / pharmacology
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Receptors, Estrogen / analysis
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Receptors, Thyroid Hormone / genetics*
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Receptors, Thyroid Hormone / physiology*
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Sexual Behavior, Animal / drug effects*
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Thyroxine / blood
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Triiodothyronine / blood
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Uterus / drug effects
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Uterus / growth & development
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Vasopressins / analysis
Substances
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Estrogens
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Receptors, Estrogen
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Receptors, Thyroid Hormone
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Triiodothyronine
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Vasopressins
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estradiol 3-benzoate
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Progesterone
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Estradiol
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Oxytocin
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Thyroxine