Differences in chlorzoxazone metabolism in full mature male and female Sprague-Dawley rat, Beagle dog and Cynomolgus monkey liver

Hum Exp Toxicol. 2000 Feb;19(2):122-5. doi: 10.1191/096032700678815738.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Aniline Hydroxylase / metabolism
  • Animals
  • Chlorzoxazone / metabolism*
  • Cytochrome P-450 CYP2E1 / metabolism
  • Dogs
  • Female
  • Liver / metabolism*
  • Macaca fascicularis
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Muscle Relaxants, Central / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Sex Characteristics
  • Species Specificity

Substances

  • Muscle Relaxants, Central
  • Cytochrome P-450 CYP2E1
  • Aniline Hydroxylase
  • Chlorzoxazone