Breakdown of tolerance to a neo-self antigen in double transgenic mice in which B cells present the antigen

J Immunol. 2000 May 1;164(9):4594-600. doi: 10.4049/jimmunol.164.9.4594.

Abstract

Transgenic (Tg) mice expressing a foreign Ag, hen egg lysozyme (HEL), under control of the alphaA-crystallin promoter ("HEL-Tg" mice) develop immunotolerance to HEL attributed to the expression of HEL in their thymus. In this paper we analyzed the immune response in double (Dbl)-Tg mice generated by mating the HEL-Tg mice with Tg mice that express HEL Abs on their B cells ("Ig-Tg" mice). The B cell compartment of the Dbl-Tg mice was unaffected by the HEL presence and was essentially identical to that of the Ig-Tg mice. A partial breakdown of tolerance was seen in the T cell response to HEL of the Dbl-Tg mice, i.e., their lymphocyte proliferative response against HEL was remarkably higher than that of the HEL-Tg mice. T-lymphocytes of both Dbl-Tg and Ig-Tg mice responded to HEL at concentrations drastically lower than those found stimulatory to lymphocytes of the wild-type controls. Cell mixing experiments demonstrated that 1) the lymphocyte response against low concentrations of HEL is due to the exceedingly efficient Ag presenting capacity of the Ab expressing B cells and 2) breakdown of tolerance in Dbl-Tg mice can also be attributed to the APC capacity of B cells, that sensitize in vivo and stimulate in vitro populations of T cells with low affinity toward HEL, assumed to be escapees of thymic deletion. These results thus indicate that T cell tolerance can be partially overcome by the highly potent Ag presenting capacity of Ab expressing B cells.

MeSH terms

  • Animals
  • Antigen Presentation / genetics*
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Antigens, Surface / analysis
  • Antigens, Surface / genetics
  • Autoantigens / genetics*
  • Autoantigens / immunology*
  • B-Lymphocyte Subsets / immunology*
  • B-Lymphocyte Subsets / metabolism
  • Cytokines / biosynthesis
  • Immunoglobulins / biosynthesis
  • Immunoglobulins / genetics
  • Inflammation / genetics
  • Inflammation / immunology
  • Lens, Crystalline / immunology
  • Lens, Crystalline / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Muramidase / immunology*
  • Muramidase / metabolism
  • Receptors, Antigen, B-Cell / analysis
  • Receptors, Antigen, B-Cell / genetics
  • Self Tolerance / genetics*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • Antigens, Surface
  • Autoantigens
  • Cytokines
  • Immunoglobulins
  • Receptors, Antigen, B-Cell
  • Muramidase